PENU-M is a
white to pale yellow crystalline powder. The solution varies
from colorless to yellow depending on the concentration. The pH
of freshly constituted solutions is between 7.3 and 8.3. Each 1
g MERREM I.V. vial will deliver 1 g of meropenem and 90.2 mg of
sodium as sodium carbonate (3.92 mEq). Each 500 mg MERREM I.V.
vial will deliver 500 mg meropenem and 45.1 mg of sodium as
sodium carbonate (1.96 mEq).
Intra-abdominal infections, skin and skin structure infections
every 8 hrs for skin & skin structure infections
1g. every 8
hrs for intra abdominal infections.Administration as Ivminfusioon over approx. 15 to 30
minutes.Doses of 1g
may also be administered as IVF bolus injection ( 5 to 20 ml )
over approx. 3-5 minutes.
with renal impairment –
clearance > 51 ml /min = Recommended dose every 8 hrs
clearance 26-50 ml /min = Recommended dose every 12 hrs
clearance 10-25 ml /min = one half Recommended dose every 12 hrs
clearance <10 ml /min = one half Recommended dose every
Mechanism of action
exerts its action by penetrating bacterial cells readily and
interfering with the synthesis of vital cell wall components,
which leads to cell death.